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Hypertonic saline solution inhibits SARS-CoV-2 replication in vitro Machado and co-workers from Brazil recently published robust biological data on the possible role of hypertonic saline solution (HS) as a prophylactic and alternative therapy option for COVID-19 in a preprint report. On the basis of their in vitro experiments in epithelial cells of monkeys (Vero cells), they were able to prove that 1.5% NaCl solution can completely block the SARS-CoV-2 replication. They assume that it is an intracellular mechanism of action and that the inhibiting effect of HS on the life cycle of the virus is due  to the depolarization of...